Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Studyopen accessImpact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study
- Other Titles
- Impact of Antidiabetic Drugs on Clinical Outcomes of COVID-19: A Nationwide Population-Based Study
- Authors
- 장한나; 문선준; 정진형; 한경도; 이은정; 이원영
- Issue Date
- Jun-2024
- Publisher
- 대한내분비학회
- Keywords
- SARS-CoV-2; COVID-19; Clinical outcome; Metformin; Dipeptidylpeptidase-4 inhibitor; Sulfonylurea
- Citation
- Endocrinology and Metabolism, v.39, no.3, pp 479 - 488
- Pages
- 10
- Journal Title
- Endocrinology and Metabolism
- Volume
- 39
- Number
- 3
- Start Page
- 479
- End Page
- 488
- URI
- https://scholarworks.bwise.kr/ssu/handle/2018.sw.ssu/49895
- DOI
- 10.3803/EnM.2023.1857
- ISSN
- 2093-596X
2093-5978
- Abstract
- Background: Inconsistent results have been reported regarding the association between the use of antidiabetic drugs and the clinical outcomes of coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of antidiabetic drugs on COVID-19 outcomes in patients with diabetes using data from the National Health Insurance Service (NHIS) in South Korea.
Methods: We analyzed the NHIS data of patients aged ≥20 years who tested positive for COVID-19 and were taking antidiabetic drugs between December 2019 and June 2020. Multiple logistic regression analysis was performed to analyze the clinical outcomes of COVID-19 based on the use of antidiabetic drugs.
Results: A total of 556 patients taking antidiabetic drugs tested positive for COVID-19, including 271 male (48.7%), most of whom were in their sixties. Of all patients, 433 (77.9%) were hospitalized, 119 (21.4%) received oxygen treatment, 87 (15.6%) were admitted to the intensive care unit, 31 (5.6%) required mechanical ventilation, and 61 (11.0%) died. Metformin was significantly associated with the lower risks of mechanical ventilation (odds ratio [OR], 0.281; 95% confidence interval [CI], 0.109 to 0.720; P=0.008), and death (OR, 0.395; 95% CI, 0.182 to 0.854; P=0.018). Dipeptidylpeptidase-4 inhibitor (DPP-4i) were significantly associated with the lower risks of oxygen treatment (OR, 0.565; 95% CI, 0.356 to 0.895; P=0.015) and death (OR, 0.454; 95% CI, 0.217 to 0.949; P=0.036). Sulfonylurea was significantly associated with the higher risk of mechanical ventilation (OR, 2.579; 95% CI, 1.004 to 6.626; P=0.049).
Conclusion: In patients with diabetes and COVID-19, metformin exhibited reduced risks of mechanical ventilation and death, DPP-4i was linked with lower risks of oxygen treatment and death, while sulfonylurea was related to the increased risk of mechanical ventilation.
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