Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lensopen access
- Issue Date
- Nov-2012
- Keywords
- Blumea balsamifera; Apigenin; Aldose Reductase Inhibition; HPLC
- Citation
- Journal of Agricultural Chemistry and Environment, v.1, no.1, pp 28 - 33
- Pages
- 6
- Journal Title
- Journal of Agricultural Chemistry and Environment
- Volume
- 1
- Number
- 1
- Start Page
- 28
- End Page
- 33
- ISSN
- 2325-7458
2325-744X
- Abstract
- To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.
- Files in This Item
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.